北京大学叶敏团队

中药药效成分

(1)中药化学    (2)中药分析    (3)中药药效


天然产物的生物合成与生物催化

(1)途径解析    (2)催化机制    (3)异源全合成

课题组科研工作
研究方向

1. 中药药效成分
(1)中药化学:中药化学成分的分离纯化、结构鉴定。
(2)中药分析:中药多组分体系的化学成分分析、质量控制、体内代谢、药代动力学。

(3)中药药效:与心血管及代谢性疾病相关的中药活性成分的发现与分子机制。


2. 天然产物的生物合成与生物催化
(1)途径解析:植物来源重要中药活性成分生物合成途径解析。
(2)催化机制:生物合成关键酶的结构解析及功能改造提升。
(3)异源全合成:以酵母、烟草为底盘的异源生物全合成。

在研项目
· 国家自然科学基金委面上项目,2023年1月-2026年12月,主持
· 国家自然科学基金委重点项目,2024年1月-2028年12月,主持
· 国家重点研发计划(合成生物学),2023年12月-2028年11月,主持
· 云南省重大科技专项计划(西南联合研究生院科技专项),2023年12月-2026年11月,主持
代表论文 
篇,总被引

迄今发表SCI论文           

次,H-index为

1.  Wang Hao-Tian#, Wang Zi-Long#, Chen Nian-Hang#, Huang Wei, Zou Jian-Lin, Tian Yun-Gang, Ye Guo, Huang Jian, Wu Rui-Bo*, Ye Min*. Insights into the mechanisms of sugar acceptor selectivity of plant flavonoid apiosyltransferases. J. Am. Chem. Soc. 2025, https://doi.org/10.1021/jacs.5c03771. 


2.  Wang Zi-Long#, Wang Hao-Tian#, Chang Guo-Wei, Ye Guo, Zhang Meng, Chen Jiang, Ye Min*. Elucidation of the biosynthetic pathway of hydroxysafflor yellow A. Nat. Commun. 2025, 16, 4489. 


3.  Zhang Meng#, Bao Yang-oujie#, Dai Zong-Lin#, Qian Zhi-Lan, Yu Hai-Shuang, Zhou Jia-Jing, Chen Yi, Wang Zi-Long, Wang Kai-Tuo, Cai Meng-Hao*, Ye Min*. Molecular and structural characterization of a chalcone di-C-methyltransferase RdCMT from Rhododendron dauricum and its application in de novo biosynthesis of farrerol in Pichia pastoris. J. Am. Chem. Soc. 2025, 147, 17132-17143.


4.  Zou Jian-Lin#, Li Hong-Ye#, Nie Bao#, Wang Zi-Long, Zhao Chun-Xue, Tian Yun-Gang, Lin Li-Qun, Xu Wei-Zhe, Hou Zhuang-Wei, Sun Wen-Kai, Han Xiao-Xu, Zhang Meng, Wang Hao-Tian, Li Qing-Yan, Wang Li*, Ye Min*. Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants. Nat. Commun. 2025, 16, 3109.


5.  Zhang Ya-Qun, Zhang Meng, Wang Zi-Long, Bao Yang-Oujie, Wang Yu-Qi, Tian Yun-Gang, Ye Lei, and Ye Min*. Identification of key post-modification enzymes involved in the biosynthesis of lanostane-type triterpenoids in the medicinal mushroom Antrodia camphorata. Angew. Chem. Int. Ed. 2025, 64, e202420104.


6.  Wang Zi-Long, Du Xue-Qing, Ye Guo, Wang Hao-Tian, Liu Yi-Zhan, Liu Chen-Rui, Li Fu-Dong, Ågren Hans, Zhou Yang, Li Jun-Hao*, He Chao*, Guo De-An*, Ye Min*. Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis. Acta Pharm. Sin. B 2024, 14, 3746-3759.


7.  Bao Yang-oujie#, Zhang Meng#, Zhang Hao-Ran, Wang Zi-Long, Zhou Jia-Jing, Yi Yang, Li Fu-Dong, Ye Lei, Li Hong-Ye, Jin Hong-Wei, He Chao*, Ye Min*. Functional characterization and protein engineering of a glycosyltransferase GcCGT to produce flavone 6,8-di-C- and 6-C-4′-O-glycosides. ACS Catal. 2024, 14, 1075-1082.


8.  Wang Hao-Tian#, Wang Zi-Long#, Chen Kuan, Yao Ming-Ju, Zhang Meng, Wang Rong-Shen, Zhang Jia-He, Ågren Hans, Li Fu-Dong, Li Jun-Hao*, Qiao Xue*, Ye Min*. Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants. Nat. Commun. 2023, 14, 6658. 


9.  Wang Zi-Long#, Wei Wanqing#, Wang Hai-Dong#, Zhou Jia-Jing, Wang Hao-Tian, Chen Kuan, Wang Rong-Shen, Li Fu-Dong, Qiao Xue, Zhou Huan*, Liang Yong*, Ye Min*. Functional characterization, structural basis, and regio-selectivity control of a promiscuous flavonoid 7,4′-di-O-glycosyltransferase from Ziziphus jujuba var. spinosa. Chem. Sci. 2023, 14, 4418-4425.


10.  Wang Zi-Long#, Gao Hao-Meng#, Wang Shuang, Zhang Meng, Chen Kuan, Zhang Ya-Qun, Wang Hai-Dong, Han Bo-Yun, Xu Lu-Lu, Song Tian-Qiao, Yun Cai-Hong, Xue Qiao*, Min Ye*. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 30816-30823. 


11.  Zhang Meng#, Li Fu-Dong#, Li Kai#, Wang Zi-Long, Wang Yu-Xi, He Jun-Bin, Su Hui-Fei, Zhang Zhong-Yi, Chi Chang-Biao, Shi Xiao-Meng, Yun Cai-Hong, Zhang Zhi-Yong, Liu Zhen-Ming, Zhang Liang-Ren, Yang Dong-Hui, Ma Ming*, Qiao Xue*, Ye Min*. Functional characterization and structural basis of an efficient diCglycosyltransferase from Glycyrrhiza glabra. J. Am. Chem. Soc. 2020, 142, 3506-3512.


12.  He Jun-Bin#, Zhao Peng#, Hu Zhi-Min, Liu Shuang, Kuang Yi, Zhang Meng, Li Bin, Yun Cai-Hong*, Qiao Xue*, Ye Min*. Molecular and structural characterization of a promiscuous C-glycosyltransferase from Trollius chinensis. Angew. Chem. Int. Ed. 2019, 58, 11513-11520.


13.  Song Wei#, Qiao Xue#, Chen Kuan, Wang Ying, Ji Shuai, Feng Jin, Li Kai, Lin Yan, Ye Min*. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem. 2017, 89, 3146-3153.


14.  Qiao Xue, Lin Xiong-Hao, Ji Shuai, Zhang Zheng-Xiang, Bo Tao, Guo De-An, Ye Min*. Global profiling and novel structure discovery using multiple neutral loss/precursor ion scanning combined with substructure recognition and statistical analysis (MNPSS): Characterization of terpene-conjugated curcuminoids in Curcuma longa as a case study. Anal. Chem. 2016, 88, 703-710.


15.  Ji Shuai, Li Zi-Wei, Song Wei, Wang Yong-Rui, Liang Wen-Fei, Li Kai, Tang Shu-Nan, Wang Qi, Qiao Xue, Zhou De-Min, Yu Si-Wang*, Ye Min*. Bioactive constituents of Glycyrrhiza uralensis (licorice): Discovery of the effective components of a traditional herbal medicine. J. Nat. Prod. 2016, 79, 281-292.